Protein Details: Aquaporin Z
Protein ID
ICDB_Pro_0658
Protein Name
Aquaporin Z
Gene Name
aqpZ; bniP; c1009
Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Length
231 amino acids
AlphaFoldDB
AF-P60845-F1-model_v4.pdb
Function
Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.
Sequence
MFRKLAAECFGTFWLVFGGCGSAVLAAGFPELGIGFAGVALAFGLTVLTMAFAVGHISGGHFNPAVTIGLWAGGRFPAKEVVGYVIAQVVGGIVAAALLYLIASGKTGFDAAASGFASNGYGEHSPGGYSMLSALVVELVLSAGFLLVIHGATDKFAPAGFAPIAIGLALTLIHLISIPVTNTSVNPARSTAVAIFQGGWALEQLWFFWVVPIVGGIIGGLIYRTLLEKRD
PDB Structures
Ligand Binding
Binding Site
SITE 20: "Involved in tetramerization or stability of the tetramer"; SITE 43: "Selectivity filter"; SITE 174: "Selectivity filter"; SITE 183: "Selectivity filter"; SITE 189: "Selectivity filter"
Disease
Location
DOI ID
10.1073/pnas.252529799
RefSeq
WP_001298299.1